Mayo Clinic study reveals disturbing impact of puberty blockers on testicular development
By Laura Harris // Apr 25, 2024

A recent study from the prestigious Mayo Clinic has uncovered evidence proving that puberty blockers cause long-lasting damage on testicular development.

The study, published as a preprint and pending peer review, used the Mayo Clinic's Pediatric Testicular Biobank for Fertility Preservation to collect testicular specimens from 87 minor individuals undergoing fertility preservation surgery for various health reasons.

Among these, 16 were gender dysphoric boys aged 10 to 16, transitioning to transgender girls between the ages of two and 15. At the time of surgery, nine patients (56 percent) were already on puberty blockers, with exposure ranging from three to 52 months.

According to the findings, two patients showed unusual features in their testicles upon examination, including incomplete development of the protective covering around the testicles and difficulty in detecting one testicle. The tissue-level analysis further revealed abnormal testicular development in males treated with puberty blockers compared to those who were not treated, with variability in outcomes observed among different patients.

In a particularly striking case, a 12-year-old patient who underwent treatment with puberty blockers for 14 months showed 59 percent atrophy of sex glands and the presence of testicular microlithiasis, a condition that could lead to testicular cancer. Single-cell analysis also stressed significant disruptions in testicular cell composition and gene expression patterns in patients treated with puberty blockers.

The study found that over 90 percent of cells responsible for sperm production in one patient treated with puberty blockers were stunted at an early developmental stage, with alterations observed in the expression of puberty-associated genes in endothelial cells. These findings suggest that puberty blockers may induce juvenile testicular atrophy and disrupt normal cell maturation processes critical for sperm production. Additionally, the study revealed significant changes in the genetic activity of early-stage sperm cells.

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In other words, puberty blockers trigger substantial cellular changes that could have long-term implications for testicular growth and sperm production. This, in turn, could affect testicular function and fertility.

Mayo Clinic debunks woke narrative about gender ideology

The study adds to the long list of research debunking the woke narrative about gender ideology.

It challenges claims from medical authorities, including from transgender-affirming voices within the Mayo Clinic itself, that administering drugs to gender-confused youth at a young age can be utilized to "delay the changes of puberty in transgender and gender-diverse youth [sic] who have started puberty."

Plenty of other evidence proves the dangers of taking puberty blockers, even among individuals who hold the mistaken belief that sex can be altered. Puberty blockers have been associated with adverse effects such as depression, suicide, infertility and reduced bone density. (Related: Study: 34% of children put on transgender puberty blockers end up becoming mental cases.)

During a conference in 2022, Scott Leibowitz, a doctor involved in the development of standards for the World Professional Association for Transgender Health, warned the public against the misconception that puberty blockers are entirely reversible.

"There’s challenges with puberty suppression that we have to acknowledge and that’s why it’s 'reversible asterisks,'" Leibowitz said. "One cannot be on puberty suppression endlessly. You get to a place where physiologically we need hormones."

Head over to for more stories about gender-related medical interventions.

Watch a detransitioned molecular biologist warn against puberty blockers in the news interview below.

This video is from the NewsClips channel on

More related stories:

Better late than never: UK to stop prescribing puberty blockers for children who experience gender dysphoria.

Biden education department unveils “Pride” seminar for children pushing them to take puberty blockers and mutilate their bodies.

Puberty blockers are QUACK medicine backed by nothing… chemical child abuse is now demanded by LGBT pushers conspiring with evil doctors.

Even Catholic hospitals are mutilating children with “gender-affirming” transgender “care.”

Biased transgender textbook used to train psychiatrists could damage millions of children, experts warn.

Sources include:

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